ea0005p210 | Reproduction | BES2003
Oxynos C
, Thakker N
, Hewitt C
, Southern L
, Anderson R
, Huhtaniemi I
, Yong E
, Wu F
BACKGROUND: Male steroidal contraceptive regimens achieve azoospermia in 60-90% of Caucasians. The mechanisms underlying this heterogeneity in response are not clear. The aim of this retrospective study was to examine a number of polymorphisms in genes involved in androgen metabolism and action, in azoospermic responders (n=73) and oligozoospermic non-responders (n=44) from previous contraceptive trials. METHODS: Local Ethical Committee approval was obtained. DNA was extracted...